Increase in aldosterone secretion by carotid artery constriction in the dog and its prevention by thyrocarotid arterial junction denervation.

Although it has been shown that the vagus nerves may carry impulses mediating decreases in the rate of aldosterone secretion (1), no equivalent pathway has been demonstrated which might mediate increases in aldosterone secretion. Because of evidence that aldosterone secretion may be increased by some function of a decreased intravascular volume (2), and the evidence cited above that this increase is not dependent upon the integrity of intrathoracic vagal receptors (1), the present experiments were designed to investigate the role of receptors located in the arterial system.